There is no best program to draw, it is mostly a matter of tastes.
To this (often asked) question the answers often given are :
Gimp, paint.net, gale graphics (all free software more or less complex).
If you have mean or want to be hype you can always check photoshop too. (but it will cost you a kidney).
For the random sounds/music, a search
on the forum would have lead you to this topic