It is odd that only using a few sprite sheets wouldn't work, but I noticed you're using the Canvas plugin. It could be a bug or memory leak in that plugin - but we can't support third-party plugins since it's not our code. If you think this is a Construct 2 bug, please report a bug
without using any third party plugins to prove it's a problem in C2 itself, but I would strongly recommend you still approach this a different way or use a different tool, because none of the systems you are using (C2, the browser, the GPU, etc.) are designed to work well this way. If you're trying to make a 3D engine then Construct 2 is not a suitable tool for this, so we may not even be able to fix bugs that occur when trying to make a 3D game in Construct 2. Sorry!