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capsules or tablets to take varies from the specific formulation and the individual's needs. For those the doses. Most people need to experience (within reason!) The dose to find the level that best suits individual needs of your child. 13. What is the best time to administer the enzymes? Preferably with the first mouthfuls of the meal or just before it. bio x4 If you forget, go ahead and take the enzymes during the meal or even at the end. The important point is to consider that the enzyme acts in contact with the.